The solitary type of Keratoacanthoma is a common, rapidly growing, benign tumor with a natural history of spontaneous involution which was first described by Hutchinson in 1889.
It was well known that this Keratoacanthoma is close resemblence to squamous cell carcinoma clinically & histopathology.
The etiology of Keratoacanthoma is uncertain but it have been associated with many exogenous factors, including sun exposure, occupational exposure to heat and trauma, and tar and with autoimmune etiology and viral infection.
We experienced 2 cases of solitary -type of Keratoacantoma with typical clinical and histopathologic findings which presented. on the pubic area and forehead but had no predisposing factors of Keratoacanthoma.
The one was 66-year-old woman who had been a history of pruritic, rapidly growing tumor on Mons Pubis since about 6 months ago.
The another one was 40 year-old male who had been a history of asymptomatic, growing tumor on forehead since about 3 months ago.
In the H-E stained sections, there were horn filled invagination, dyskeratotic
cell, horn pearl in the epidermis. and an inflammatory infiltration in dermis. Diagnosis was confirmed by the clinical and histopathological pictures.
The former was treated by electrocautery after simple excision and the latter by
curretage and electrodesiccation.
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